RESEARCH
Synthesizing Small Molecule Fluorogenic Probes for Biomarker Detection
Tracking of biologically relevant molecules and proteins in cells is an ongoing issue in biomedical research. Biomarkers are measurable substances that can indicate presence and/or progression of diseases. Small molecule fluorescent probes would allow clinicians to monitor disease progression in a minimally invasive manner. The Gilyot Lab works to design and synthesize new small molecule fluorophores for detection of cancerous and non-cancerous biomarkers.
Development of Small Molecule Fluorogenic Probes for Detection of Neuropeptides
Neuropeptides are a large and diverse class of signaling molecules that are synthesized and released by neurons. They primarily act as signaling molecules and neuromodulators that act via binding to cellular surface receptors called G-protein coupled receptors (GPCRs). Due to their high affinity for GPCRs, a small concentration of the neuropeptide can still adequately activate the receptor. Highly sensitive small molecule organic fluorophores would be highly useful for detection of neuropeptides at low concentrations. The Gilyot Lab works to design and synthesize small molecule fluorogenic probes for detection of neuropeptides.